b'V A S H EW O U N D S O L U T I O NProven EffectivenessVashe Wound Solution has been tested against many common pathogens, including fungi, spores, and multi-drug-resistant bacterial strains. In clinical studies, the organisms are mechanically removed from the wounds in great numbers, allowing the immune system to sustain the reductions. 13-15Organism Time to kill % Reduction Organism Time to kill % ReductionMRSA 15 seconds 99.999% Micrococcus luteus 15 seconds 99.999%VRE 15 seconds 99.999% Proteus mirabilis 15 seconds 99.999%Escherichia coli 15 seconds 99.999% Pseudomonas aeruginosa 15 seconds 99.999%Acinetobacter baumannii 15 seconds 99.999% Serratia marcescens 15 seconds 99.999%Bacteroides fragilis 15 seconds 99.999% Staphylococcus epidermidis 15 seconds 99.999%Candida albicans 15 seconds 99.999% Staphylococcus haemolyticus 15 seconds 99.999%Enterobacter aerogenes 15 seconds 99.999% Staphylococcus hominis 15 seconds 99.999%Enterococcus faecium 15 seconds 99.999% Staphylococcus saprophyticus 15 seconds 99.999%Haemophilus influenzae 15 seconds 99.999% Streptococcus pyogenes 15 seconds 99.999%Klebsiella oxytoca 15 seconds 99.999% Staphylococcus aureus 15 seconds 99.995%Klebsiella pneumoniae 15 seconds 99.999% C. difficile endospores 15 seconds 99.93%MINIMAL CHANCE OF RESISTANCE TO HOCl COMES DOWN TO MECHANISMS OF ACTIONMicrobial cell wall or protective layer Antibiotic resistance is of increasing concern to clinicians and hospital administrators alike. Antibiotics and antimicrobials Hypochlorous acidsuch as silver and chlorhexidine gluconatesometimes used H molecule (HOCl) to cleanse woundshave documented resistance to various Penetrate (acts from the inside) O H H strains of bacteria. 16-18There has been no resistance reported to Cl O O Uncharged hypochlorous acid. This lack of resistance removes the chances Cl Cl that the hypochlorous acid may lose its preservative efficacy in Degeneration the bottle. This molecule is native to humans and is reported to have several possible mechanisms of antimicrobial action to Destruction kill bacteria in vitro. These may be responsible for the lack of documented resistance to hypochlorous acid.McKenna and Davies reviewed the inhibition of bacterial growth by hypochlorous acid. 19They concluded that even low concentrations of hypochlorous acid exert a rapid and selective inhibition of bacterial cell growth and cell division. In brief, they also observed that hypochlorous acid can oxidize nucleotides, inactive enzymes, and the electron transport system; disrupt cell membranes; and fragment proteins. Their work, and that of others, describes a molecule that can apparently impact several critical bacterial cell functions.'